本周二北大讲座ATM阻止导致B细胞淋巴瘤

生命中心通知讲座科研阅读学生我们是交叉，一切皆有可能...主题：ATMpreventsRAG-initiateddouble-strandedbreakstoformdicentricchromosomesthatleadtoBcelllymphomas主讲人：JiazhiHu,Ph.D.ResearchFellowinDr.FrederickAlt’slabBostonChildren’sHospital时间：-04-:30地点：北京大学新生物楼摘要：ATMisthemasterkinaserespondingtoDNAdouble-strandedbreaks(DSBs).IntheabsenceofATM,DSBscanpersistandformtranslocationsthatparticipateintumorigenesis.WegeneratedmousemodelsrecurrentlydevelopingBcelllymphomasintheabsenceofATM,andfoundallthetumorsarosefromdicentricchromosomesinvolvingRAG-generatedDSBsintheIgHlocus.Weemployedahigh-throughputsequencingmethodtotrackDSBsintheATM-deficientcells,andfoundATMDNAdamageresponsepathwaycouldtetherbrokenendsfromthesameDSBstogethertofacilitatetheirre-joining,andthuspreventedtheformingoftranslocationsincludingdicentricchromosomes.Inaddition,wefoundthattheRAGendonuclease,whichisessentialforV(D)Jre







































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